Title | A trial to reduce hepatitis C seroincidence in drug users |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Stein, MD, Herman, DS, Anderson, BJ |
Journal | Journal of Addictive Diseases |
Volume | 28 |
Pagination | 389-398 |
Publisher | Taylor & Francis |
Place Published | United Kingdom |
Publication Language | eng |
ISBN Number | 1055-08871545-0848 |
Accession Number | 2010-12074-010. First Author & Affiliation: Stein, Michael D. |
Keywords | Drug abuse, Harm Reduction, Hepatitis, hepatitis C virus seroincidence, injection drug usage, Intervention, Intravenous Drug Usage, Motivational intervention, motivational interviewing, prevention, Treatment Effectiveness Evaluation |
Abstract | To test whether a four-session motivational intervention would reduce hepatitis C virus (HCV) seroincidence among injection and non-injection drug users compared to an assessment-only condition, we performed a randomized 24-month clinical trial. At baseline, 277 participants reported using heroin or cocaine at least three times weekly were HCV antibody negative, 65% were male and 46% were Caucasian and 39% reported having injected drugs. Of the 15 (5.4%) individuals who seroconverted, all reported injecting drugs either at baseline or during follow-up. Seroconversion rates did not differ significantly by treatment assignment (p = .79). The annual HCV incident rate was 8.20 (95% confidence interval [CI] = 4.76-14.13) for injectors and 0.74 (95% CI = 0.19-2.98) for non-injectors per 100 person-years. Significantly fewer participants in the intervention group initiated injection drug use behaviors (p = .009). This intervention was no more effective at reducing HCV seroconversion than assessment alone but did decrease injection initiation. (PsycINFO Database Record (c) 2010 APA, all rights reserved) (journal abstract) |
URL | http://libproxy.unm.edu/login?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-12074-010&login.asp&site=ehost-live&scope=siteMichaelhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822987/pdf/nihms135801.pdf |