A randomized controlled trial to enhance antiretroviral therapy adherence in patients with a history of alcohol problems

TitleA randomized controlled trial to enhance antiretroviral therapy adherence in patients with a history of alcohol problems
Publication TypeJournal Article
Year of Publication2005
AuthorsSamet, JH, Horton, NJ, Meli, S, Dukes, K, Tripps, T, Sullivan, L, Freedberg, KA
JournalAntiviral Therapy
Volume10
Pagination83-93
Publication Languageeng
ISBN Number1359-6535 (Print)1359-6535 (Linking)
Accession Number15751766
Keywords*Patient Compliance, Adult, Alcoholism/*complications/psychology, Anti-HIV Agents/*therapeutic use, Behavior Therapy, Boston, Female, HIV Infections/*complications/*drug therapy/psychology, Humans, Male, Middle Aged, Treatment Outcome
Abstract

OBJECTIVE: To assess the effectiveness of an individualized multicomponent intervention to promote adherence to antiretroviral therapy (ART) in a cohort of HIV-infected individuals with a history of alcohol problems. DESIGN: We conducted a randomized controlled trial to compare the usual medical follow-up with an adherence intervention. SETTING: The principal enrolment site was Boston Medical Center, a private, not-for-profit, academic medical institution. SUBJECTS: HIV-infected patients with a history of alcohol problems on ART. A total of 151 were enrolled and 141 (93%) were assessed at follow-up. Intervention: A nurse, trained in motivational interviewing, completed the following over 3 months in four encounters: addressed alcohol problems; provided a watch with a programmable timer to facilitate pill taking; enhanced perception of treatment efficacy; and delivered individually tailored assistance to facilitate medication use. MAIN OUTCOME MEASURES: Prior 30-day adherence > or =95%, prior 3-day adherence of 100%, CD4 cell count, HIV RNA and alcohol consumption, each at both short- and long-term follow-up. RESULTS: At follow-up, no significant differences in medication adherence, CD4 cell count, HIV RNA or alcohol consumption were found (all P values >0.25). CONCLUSIONS: A multicomponent intervention to enhance adherence among HIV-infected individuals with a history of alcohol problems was not associated with changes in medication adherence, alcohol consumption or markers of HIV disease progression. The failure to change adherence in a group at high risk for poor adherence, despite utilizing an intensive individual-focused patient intervention, supports the idea of addressing medication adherence with supervised medication delivery or markedly simplified dosing regimens.

URLhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15751766
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